Figure 2: Retinoblastoma protein and cell-cycle progression. Recent experiments have implicated one specific E2F target, CDC6, as a potentially important marker for quiescence. CDC6 has a crucial ...

Cell-cycle activation in quiescent cells is correlated with a change in chromatin structure and requires the activation of the retinoblastoma (RB)–E2F pathway. The gain of a new cell fate is ...