The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

formed by the proteins CXCR4 and CXCL12, folinic acid allows immune cells to infiltrate and attack the tumor. “Folinic acid enhances that response,” explains Fearon. “T cells respond to ...

This effect is associated with increased infiltration and activation of cytotoxic T lymphocytes and prolonged survival. These new insights into the role of CXCR4 in dendritic cells may help ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

Surface-bound MIF induced arrest of primary human monocytes through CXCR2 and triggered the arrest of primary human effector T cells via CXCR4. Furthermore, CD74 (a MIF-binding protein ...

Following this, Exicure intends to receive technology transfer for GPCR Therapeutics’ CXCR4 inhibitor ... preclinical data on boosting T cell responses to offer various therapies, including ...