Professor Kevin J. Zwezdaryk and Chandler H. Monk discuss CRISPR and diagnostics, focusing on the development of a portable ...

The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Yet others, called base editors, change one letter of the DNA code to another. So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA. They add bits of viral DNA to ...

The new Express License service removes barriers to accessing this transformative gene editing technology for startups.An ...

Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA ... We have investigated the binding of anti-CRISPR proteins to the crRNA-bound type I-F Csy Cascade system in collaboration ...

Researchers have been working to find CRISPR/Cas nucleases with greater specificity ... team used a GFP activation expression reporting system to screen 13 Cas12b nucleases. Interestingly, one ...

Ongoing launch of CASGEVY® continues to gain momentum--2025 is poised to be a catalyst-rich year with key updates across several ...

Treatments for rare diseases are hard to create and expensive to deliver, but there is new hope for editing the software of ...

物理隔离是实现”一管式”CRISPR检测的最直接方法，常见的方式是通过特制的隔离介质将扩增和酶切反应固定于两个腔室中，扩增后再通过手动操作将酶切体系和扩增产物混合，但这种方式仍面临试剂固定稳定性、操作复杂等挑战。微流控芯片通过集成多个反应室于单一反应 ...

2024年12月16日，生命科学学院刘亮教授团队在《Nucleic Acids Research》期刊上在线发表了题为“DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems”的研究论文，首次揭示了靶标核酸的 ...