Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada (C.S., K.J.R). Centre for Infection, Immunity ...

Paraquat (1,1’-dimethyl-4,4’-bipyridyl dichloride) is a non-selective herbicide still widely used in agricultural crops in vast regions around the world for weed control (Zobiole et al. 2018) and also ...

Upregulation of CD36 intensifies lipid influx. From a mechanistic perspective, TREM2 restrains the phosphorylation of p38 mitogen-activated protein kinase and peroxisome proliferator ...

Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm SE-171 77, Sweden Larodan Research Laboratory, Karolinska Institutet, Stockholm SE-171 77, ...

This landmark study elucidates the intricate structural mechanisms by which both covalent and non-covalent synthetic ligands can co-occupy the binding pocket of the nuclear receptor transcription ...

Crystal structures of PPARγ LBD in the transcriptionally active and repressive conformations. The active LBD (PDB 6ONJ) is stabilized by agonist (rosiglitazone) and coactivator peptide (TRAP220/MED1), ...

Efficient clearance of apoptotic cells, termed efferocytosis, critically regulates normal homeostasis whereas defective uptake of apoptotic cells results in chronic and non-resolving inflammatory ...

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and is strongly associated with obesity, dyslipidaemia and altered glucose regulation. Previous ...

Figure. Evidence from genetically manipulated murine models of FA transporting protein depicts attribution of lipid accumulation (cardiac steatosis) to cardiac remodeling, mitochondrial damage and ...