COM-701 is under clinical development by Compugen and currently in Phase II for Endometrial Cancer. According to GlobalData, Phase II drugs for Endometrial Cancer have a 22% phase transition success ...

To induce CD28 co-stimulation, we used anti-CD28 antibodies or natural ligands, B7.1 and B7.2. These natural ligands are recombinant proteins containing the extracellular region of B7.1 or B7.2 fused ...

Furthermore, there are several other stimulatory signals, namely: CD28, CD80 (B7-1) or CD86 (B7-2), which are also essential for the activation of T cell lymphocytes. But to prevent the ...

Here we initially performed a detailed analysis of T cells expressing B7-H3-CARs with different hinge/transmembrane (CD8α vs CD28) and CD28 or 41BB costimulatory domains (CD8α/CD28, CD8α/41BB, ...