Given that wt p53 induces apoptosis in response to adenovirus E1a proteins 12, the absence of virus induced CPE in mutant p53 cells could result from an inability of the virus to induce p53 ...

Moreover, an apoptosis-independent mode of programmed cell death, termed necroptosis, has been identified and described in the intestinal epithelium. The following article reviews previous studies on ...

Among the victims of caspases are many cytoskeleton components (such as actin, gelsolin, β-catenin, focal adhesion kinase) and proteins involved in signalling pathways, in apoptosis regulation ...

Dgkζ overexpression increased proteasomal p53 degradation and attenuated cardiomyocyte apoptosis after doxorubicin stimulation in cardiomyocytes, which was reversed by knockdown of E6ap. Dgkζ ...

Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient p53-independent ... The compartmentalization of eukaryotic cells, facilitated ...

Thus, we next used siRNA to knock down the p53 protein in MGC-803 cells. An Annexin V-APC/7-AAD apoptosis assay revealed that NOLC1 single-knockdown cells were more sensitive to Cis than were NC cells ...

Vascular proliferation contributes to the pathobiology of atherosclerosis and is linked to other cellular processes such as inflammation, apoptosis and matrix alterations. The contribution of ...

He, H.J., Cen, X.H., Liang, Y.J., Zhong, J.M., Deng, J.H. and Jiang, Y.J. (2025) Progress in the Regulation of Lipid Metabolism by the Orphan Nuclear Receptor Nur77. Journal of Biosciences and ...

Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...

When it comes to financial regulation in America, “no rational person would have set out to design the current system of regulation. It is inefficient and inequitable, sometimes completely ...

1 Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic (ASCR), Prague, Czechia 2 Second Faculty of Medicine, Charles University, Prague ...

The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...