The action of MTX may occur through inhibition of folate pathway enzymes; however, more recent reports indicate that the efficacy of MTX is related to release of endogenous adenosine (see Figure 1).

School of Biotechnology and Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China ...

Summarizing these molecular mechanisms, it can be seen that the gene polymorphisms of MTX transporters, as well as those of the enzymes in the folate and adenosine pathways, are the focus of ...