Now, new research in Nature Structural & Molecular Biology describes how the enzyme RapA prevents R-loop formation in E. coli, with far-reaching implications for how all cells mai ...

Sixteen students from The Gatton Academy of Mathematics and Science at Western Kentucky University presented their research ...

Students from The Gatton Academy of Mathematics and Science at Western Kentucky University presented their research in Frankfort at the Kentucky Junior Academy of Science meeting, held in tandem with ...

Recent Pipeline Progress & Upcoming Milestones of Prioritized Clinical Programs: Repare is evaluating RP-1664 as a ...

The high sales figures for gastric drugs reflect a growing health concern in Bangladesh related to dietary habits and lifestyle choices ...

Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

Obese mice whose fat cells were genetically altered to produce an increased amount of the glucose-dependent insulinotropic ...

An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

在此基础上，他们又进一步探索，最终找到了石胆酸的分子靶点——TULP3，并发现了TULP3能够通过激活sirtuin-v-ATPase信号轴，激活在卡路里限制中起到延缓衰老关键作用的AMPK（AMP-activated protein kinase）蛋白，从而延缓衰老。相关工作分别以“Lithocholic acid phenocopies anti ...

Schematic diagram showing that the v-ATPase serves as a common entry into the lysosomal AMPK pathway. Credit: Nature (2024). DOI: 10.1038/s41586-024-08348-2 ...

Consistently, the KIF4A SLiM peptide alone is sufficient to stimulate ATPase and DNA loop extrusion activities of condensin I. We identify similar SLiMs in the known yeast condensin interactors, Sgo1 ...