Scientists reveal mechanism of key player in lysosome transport regulation
A research team led by Prof. Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant ...
Decoding the link between lysosomal activities and focal adhesions could aid cancer research
The fight against cancer often begins with uncovering hidden players, and a recent study reveals one such key player: an ...
Nature12 年
The Discovery of Lysosomes and Autophagy
De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...
EurekAlert!3 天
Insight into link between lysosomal activities and focal adhesions and implications for ...
The fight against cancer often begins with uncovering hidden players, and this study reveals one such key player: an ...
Chemists discover a key protein in how lysosomes work
Lysosomes, often reductively referred to as the "garbage disposals" of cells, play a pivotal role in our cells' digestive systems by getting rid of unwanted materials.
pharmaphorum3 天
MSD reaches $610m deal to buy lysosome biotech Caraway
The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...
Baylor College of Medicine2 年
TFEB and V-ATPase-mediated Lysosomal Stress Sensing Pathway in Tauopathy
Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...
ALZFORUM29 天
Sans Presenilin-2, Lysosomes Struggle. Synapses, Memory Circuits Erode
While PSEN1 prefers to bask on the cell surface and sometimes ventures into the early endosomes, PSEN2 contains a sorting sequence that strictly restricts it to late endosomes and lysosomes. As such, ...