Figure 1: Discovery of the ligation of ubiquitin to lysozyme, a substrate of the proteolytic system. As indicated before 19, the main lesson from our story is the continued importance of the use ...

Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

Some cancer drugs cause severe side effects because they are not working accurately enough. A team at the University of Würzburg led by biochemist Caroline Kisker has now discovered why.

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases ...

Scientists have uncovered how developing neurons migrate from the germinal zone, a process critical for proper brain circuit ...

Most of our prior work focused on the Ubl protein SUMO as it is essential in budding yeast and its conjugation to substrates requires an enzyme cascade that involves fewer factors in comparison to the ...

We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like ...