Andy Extance charts how research into revolutionary targeted protein degradation therapies is moving from serendipity to ...

The journey of a thousand miles begins with a single step, but for developing neurons, this first step relies on ...

Scientists have uncovered how developing neurons migrate from the germinal zone, a process critical for proper brain circuit ...

The journey of a thousand miles begins with a single step, but for developing neurons, this first step relies on collaboration from multiple signaling pathways.

Ubiquitin-specific proteases (USPs) play a crucial role in tumor progression, regulating the stability or functions of specific substrate proteins. USP33 expression is altered in several types of ...

Biopolar Hongye (Nantong) Pharmaceutical Co., Ltd. has described proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase cereblon (CRBN) binding moiety covalently linked to a Bruton ...

The authors note that one grant number (2021R1A2C3003518) was omitted. The affected sentence of the Acknowledgments should read: “This study was supported by grants from the National Research ...

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases ...