By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...
Specially packaged DNA secreted by tumor cells can trigger an immune response that inhibits the metastatic spread of the tumor to the liver, according to a new study. The discovery improves the ...
This has resulted in greater attention to 3D cell culture technologies that are more physiologically relevant and predictive models for drug discovery and development. These technologies have become ...
Table 2 shows the tissue-culture criteria for evaluation of chemotherapeutic agents on tumor cells. Here, as in the clinical study, grades were used: 0 means that no effect, 1 a questionable ...
Researchers describe two enzymes newly identified for their roles in regulating macropinocytosis, a process cancer cells use to snatch extra nutrients from the jelly-like substance between cells.