Overall structure of RmlC RmlC is a ‘mainly beta’ class protein with a jelly roll-like topology. The fold of the main chain is shown in Fig. 2. RmlC monomers have a globular shape with ...

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On track to report updated overall survival data for CAN-2409 from phase 2a clinical trials in pancreatic ductal adenocarcinoma (PDAC) and ...

In brief, DG44-CHO cells were cultured in IMDM (098-06465, FUJIFILM Wako Pure Chemical Corporation, Osaka, Japan) containing 0.1 mM hypoxanthine, 0.016 mM thymidine, 0.002 mM methotrexate (MTX), 50 µM ...

A model showing how metallic bonds are formed - the first diagram shows the outer electrons in their atoms, and the second diagram shows that the electrons have become delocalised ...

1 Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Institute of Structural Pharmacology and TCM Chemical Biology, Fujian University of Traditional Chinese Medicine, Fuzhou, China ...

A good example of this is the insertion of the HSV-1 thymidine kinase gene into a tumour ... Viral mutant: A virus which has had a part of its genetic structure altered leading to a detectable ...

The hypoxic cell sensitizers (e.g. misonidazole), and thymidine analogs (e.g. bromodeoxyuridine) are examples of 'true' radiosensitizers; however, the radiosensitizers most commonly used today ...

During the 2024 American Association for Cancer Research (AACR) Annual Meeting, we reported preclinical data for the first-in-class, tertiary lymphoid structure (TLS) inducer viral immunotherapy ...