We are interested in mechanisms that regulate RNA Stress Granule (SG) and Processing Body (P-body ... We found that poliovirus 3Cpro cleaves a protein called G3BP that is critical for nucleating SG ...

One of the virus's proteins binds to G3BP and prevents the formation of so-called stress granules, which would otherwise have an antiviral effect. "Our research shows that SARS-CoV-2 reprograms ...