Your body is a collection of cells carrying thousands of genetic mistakes accrued over a lifetime—many harmless, some bad and ...

Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately 20 ...

Published in Cell, the study titled, “Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease,” ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

The versatility of induced pluripotent stem cells in regenerative medicine, disease modeling, drug discovery, and personalized therapy underpins their growing demand. Additionally, advancements in ...

report a single-SALL4-mediated somatic reprogramming method and reveal the underlying mechanism of this process. Efficient and multiplex precise editing in human pluripotent stem cells (hPSCs ...

The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic ...

Their collaboration has resulted in engineered cells called ‘synthetic organizers’ that deliver instructions to stem cells, telling them to grow into specific tissues and organs.