Sethi emphasized the need for studies like this one that shed light on the molecular details of how serrated adenomas form and progress ... deletion of one or both aPKC in intestinal epithelial cells, ...

2006;3(5):267-274. An adaptation of the Vogelstein adenoma:carcinoma sequence. The acquisition of a mutation (or 'hit') in a stem cell within a crypt results in dysplastic progeny and leads to ...