Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

This study can potentially contribute to the comprehensive knowledge on the pathway by which stem cells respond to NIC, a major component of cigarette smoke, and suggest an effective new strategy for ...

The manuscript by Isotani et al characterizes the hyperproliferation of intestinal stem cells (ISCs) induced by nicotine treatment in vivo. Employing a range of small molecule inhibitors, the authors ...

The clinical finding of malabsorption after massive resection of the small ... new types of stem cells, signaling molecules, and bioactive scaffolds for the tissue-engineered intestine will ...

Small intestinal epithelium and crypts were isolated as previously described.29 30 Cell pellets were either resuspended in RLT Buffer (Qiagen, supplemented with β-mercaptoethanol 10 µl/mL) to be used ...

Background Aberrant Wnt pathway activation is a key driver of colorectal cancer (CRC) and is essential to sustain tumour growth and progression. Although the downstream protein-coding target genes of ...

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, ...

germ cell tumors, epithelial ovarian, fallopian tube, primary peritoneal carcinoma, non muscle invasive bladder cancer (first line therapy), hepatocellular carcinoma (as first line and second line ...

Department of Chemistry, Beckman Institute for Advanced Science and Technology, and Cancer Center at Illinois, University of Illinois Urbana−Champaign, Urbana, Illinois 61801, United States ...

also known as adenocarcinoma, is a rare form of cancer that often doesn’t cause signs or symptoms in the early stages. PAY ATTENTION: TUKO is in WhatsApp Channels now! Subscribe and read news in ...

Their collaboration has resulted in engineered cells called ‘synthetic organizers’ that deliver instructions to stem cells, telling them to grow into specific tissues and organs.