2006;3(5):267-274. An adaptation of the Vogelstein adenoma:carcinoma sequence. The acquisition of a mutation (or 'hit') in a stem cell within a crypt results in dysplastic progeny and leads to ...

Sethi emphasized the need for studies like this one that shed light on the molecular details of how serrated adenomas ... think about normal stem cells dying when colon cancer is starting,” Sethi ...