Recent studies suggest that activated pancreatic stellate cells (PSCs) play a central role in pancreatic fibrogenesis via increased synthesis of ECM proteins. However, the role of these cells in ECM ...

The relationship the immune system and stromal cells in pancreatic cancer can have a significant impact on patients' survival rates, according to findings of a Queen Mary-led study. Pancreatic ...

The study investigated the potential interactions between these stromal cells (also known as pancreatic stellate cells or cancer associated fibroblasts) and a specific type of immune cells called ...

Isolated alcoholic binges rarely, if ever, cause pancreatitis. Pancreatic stellate cells have been identified as the key effector cells in the regulation of pancreatic fibrosis. Activation of ...

The tumour microenvironment consists of activated fibroblasts, pancreatic stellate cells, infiltrating immune cells, macrophages and soluble growth factors and cytokines that are secreted in the stiff ...

pancreatic stellate cell; Shh, sonic hedgehog; TME, tumor microenvironment. Another ECM-targeting strategy is pamrevlumab, a monoclonal antibody that inhibits the activity of connective tissue growth ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

which promotes the proliferation and migration of tumor cells. The tumor microenvironment of pancreatic cancer is essentially a dense matrix formed by excessive fibrosis caused by active connective ...

The activation of hepatic stellate cells (HSCs) is involved in hepatoma progression, and accumulating evidence demonstrates a change in microRNA (miRNA) expression during HSC activation. Therefore, ...

Rather than limiting their growth to more sustainable rates, cancer cells adapt by finding alternative ways to scavenge what they need. One scrounging strategy prevalent in pancreatic ductal ...

An organoid containing all three pancreatic cell lineages has been developed for the first time, providing a clearer picture of how the pancreas develops. Organoids can help us better understand ...