PKM2 acts as a critical nonmetabolic regulator of macrophage pyroptosis by increasing NLRP3 expression promoting NLRP3 inflammasome activation via nuclear translocation and enhancing STAT3 ...

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Tumor-associated macrophages (TAMs) are considered to play a critical role in the tumor microenvironment (TME) and increase the aggressiveness of hepatoma. The activation of hepatic stellate cells ...

kuleuven.be Intestinal resident macrophages are at the front line of host defence at the mucosal barrier within the gastrointestinal tract and have long been known to play a crucial role in the ...

Ferroptosis is a programmed cell death caused by iron‐dependent accumulation and cellular lipid peroxides, which is different from apoptosis and pyroptosis. This study investigated the possible effect ...

The PKM2 inhibitor shikonin has been found to reduce the activation of NLRP3 inflammasomes ... Baatarjav et al. found that AIM2 deficiency leads to macrophage accumulation and impaired renal function ...

Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, ...

In vivo synovial tissue oxygen (tpO 2 mmHg) was measured in patients with inflammatory arthritis (n=42) at arthroscopy, and markers of glycolysis/oxidative phosphorylation (glyceraldehyde 3-phosphate ...