In addition, although p53/mutant p53 have been raised to the core position of the signaling network of cancer, the translation of our knowledge into clinical use remains limited. This collection of ...

Keywords: p53 mutation, breast cancer, gain-of-function, therapy, tumor suppression, TNBC, Signaling Pathways Important Note: All contributions to this Research Topic must be within the scope of the ...

Westlake University in China and the California Institute of Technology have designed a protein-based system inside living ...

Researchers have identified a molecular mechanism driving the structural abnormalities leading to lissencephaly that have ...

Overall, this fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. The evidence supporting the ...

More information: Ricardo A. Cordova et al, Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer, Science Signaling (2024).

Several components of the hedgehog (Hh) pathway are crucial to basal cell ... The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC development is increasingly recognized.