Macrophages, a type of innate immune cell ... In this study, we designed and synthesized cerium oxide nanoparticles encapsulating Nrf2 plasmids (CeO 2 /Nrf2 nanocomposites) to synergistically target ...

Ferroptosis is involved in the involution of hemangiomas. Glutathione peroxidase 4‐mediated ferroptotic resistance in macrophages, which could be promoted by hemangioma‐derived stem cells, occurs in ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

Current studies pictured the enteric nervous system and macrophages as modulators of neuroimmune processes in the inflamed gut. Expanding this view, we investigated the impact of enteric ...

Ferroptosis was determined by MDA levels, SOD levels, mitochondrial iron accumulation and ROS production. Ferroptosis-related proteins Slc7a11, Nrf2 and Gpx4 levels were measured by western blot, ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

*仅供医学专业人士阅读参考敌人的敌人不一定是朋友，但敌人的朋友很大概率还是敌人，奇点糕总在介绍的针对肿瘤微环境里“帮凶”的研究，就很能体现这个道理不是？而癌细胞表面表达的PD-L1，当然是制约抗肿瘤免疫应答的敌人，所以帮助PD-L1存在的“敌人的朋友 ...

Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.

Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical studies have implicated macrophage-mediated immune tolerance. Hence, pathways ...

aCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, ...