Zai Lab Limited today announced that China's National Medical Products Administration (NMPA) has accepted the New Drug Application (NDA) for KarXT for the treatment of schizophrenia in adults. "There ...

Muscarinic receptors are involved with neurotransmission via acetylcholine and glutamate, and are hypothesised to be dysfunctional in schizophrenia. Most drugs developed to treat schizophrenia to ...

Corticotropin-releasing factor 1 receptors; M1/2R, Muscarinic acetylcholine 1 and 2 receptors; nAchR, Nicotinic acetylcholine receptors; OXTR, Oxytocin receptors; OX1R, Orexin 1 receptors; SSRIs, ...

Cholinergic drugs (acetylcholine and methacholine ... both events explain the increase in airway resistance. Muscarinic (M) receptors involved in the airway tone regulation are as follows ...

Anticholinergics are competitive inhibitors of acetylcholine at muscarinic receptors (mainly the M3 receptor subtype), and they thereby inhibit involuntary bladder contractions. [19] The effective ...

Acetylcholine is the commonly used pharmacological agent for spasm provocation. We aimed to investigate an association between severity of symptoms and provocative acetylcholine dose. We included ...