A study led by Turkish researcher Pinar Ayata unveiled a critical mechanism involving microglia—specialized immune cells in the brain—that could open new avenues for treating Alzheimer's ...

A chronic gut infection caused by a common virus may be linked to the progression of Alzheimer ’s disease, a new study has ...

Electron micrographs show typical microglia in the prefrontal cortex of a 92-year-old healthy female (left) and dark microglia a 91-year-old female patient with Alzheimer’s disease (right).

Microglia’s stress response drives toxic lipid production linked to Alzheimer’s progression. Blocking stress or lipid pathways reversed synapse loss in preclinical Alzheimer’s models. Findings ...

Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired ...

SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia.

This study describes a valuable new model for in vivo manipulation of microglia, exploring how mutations in the Adar1 gene within microglia contribute to Aicardi-Goutières Syndome. The methodology is ...

The study highlights microglia, the brain's primary immune cells, as central players in both the protective and harmful responses associated with the disease. Researchers with the Advanced Science ...