Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

Department of Medicine, University of Erlangen-Nuremberg, Hartmannstrasse 14, 91 054 Erlangen, Germany; christoph.becker{at}uk-erlangen.de Intestinal epithelial cells (IEC) are organised as a single ...

barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription ...

For an up-to-date version of the latest best practices for single-cell RNA-seq analysis (and more modalities ... repository is a case study where the best-practices established in the manuscript are ...

The host is under selective pressure to maintain a beneficial microbiota population throughout the intestine. To do so, the host can impose several ecological ‘filters’ that can shape the composition ...

The researchers then tested whether mucus-producing cells derived from human intestines took up these particles in culture over a 24 ... human health," said study co-author Dr Alba García ...

Nat Clin Pract Gastroenterol Hepatol. 2006;3(5):267-274.

This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal ... to the crypt culture medium as required for the specific ...

HSV-1 virions gain entry to epithelial cells by fusing with the plasma membrane envelope. Subsequently, the envelope protein and capsid, which contain the linear viral genome, are released into the ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. For complex systems such as polymersomes, a key to successful ...