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Objectives Casein kinase II (CK2) is a constitutively active serine/threonine protein kinase that plays a key role in cellular transformation and tumorigenesis. The purpose of the study was to ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists ... gelatinases (MMP-2,-9) and fibroblast activation protein; [38] (3) stromelysins (MMP ...

Besides canonical hedgehog signalling with smoothened (SMO)-dependent activation of GLI transcription factors ... signalling were analysed in cultured fibroblasts, in bleomycin-induced pulmonary ...

Experiments showed that FASN was elevated in lung scar tissue from IPF patients, and its inhibition suppressed the activation of fibroblast cells, which are the main drivers of tissue scarring during ...

Ke, X. and Ma, T. (2025) Protective Effect of Liraglutide on Early Renal Fibrosis in Diabetes Mice. Journal of Biosciences and Medicines, 13, 84-91. doi: 10.4236/jbm.2025.131008 .

In this study, we found that RAGE in BECs is required for the activation and expansion of these cells into the parenchyma upon chronic liver injury in a cell-intrinsic manner. This study further ...

Department of Respiratory and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Respiratory Health, Frontiers Science Center for Disease-related ...

Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea Department of Health Sciences and Technology, SAIHST, Sungkyunkwan ...