Layer 5 pyramidal neurons, crucial for brain information processing, vary significantly in their synaptic protein composition based on neuron type.

Scientists at Yale and the University of Connecticut have taken a major step in understanding how animal brains make decisions, revealing a crucial role for electrical synapses in “filtering” sensory ...

Although Nlgn1 and Nlgn2 are highly homologous and biochemically interact with the same extra- and intracellular proteins, Nlgn1 selectively functions in excitatory synapses whereas Nlgn2 functions in ...

Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.

“It would be interesting to investigate whether improving endolysosomal function, as we did in aged neurons, recovers synapses,” she wrote. Almeida found that restoring the acid pH of lysosomes ...

However, the role of inhibitory synapses in such processes remains elusive. In this opinion paper, following a general introduction on the impact of the synaptic input spatial distribution in neuronal ...

Therefore, understanding microcircuit function requires synapse-specific investigation. However ... Using optomapping, we tested 15,433 candidate excitatory synaptic inputs to reveal 1,184 connections ...

This work is a continuation of a previous paper from the Arnold group, where they engineered GFE3, which allows to specifically ablate inhibitory synapses. Here, the authors generate 3 different ...

The device exhibits favorable synaptic behaviors, such as excitatory postsynaptic current, paired pulse facilitation, and photoelectric potentiation-depression. Subsequently, an artificial neural ...