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Although Nlgn1 and Nlgn2 are highly homologous and biochemically interact with the same extra- and intracellular proteins, Nlgn1 selectively functions in excitatory synapses whereas Nlgn2 functions in ...

The Seth Margolis Laboratory studies the signaling pathways that regulate synapse formation during normal brain development to try to understand how, when these pathways go awry, human cognitive ...

Activating excitatory neurons significantly promoted functional recovery and inhibited microglia-mediated synaptic pruning after stroke. Furthermore, it decreased EPS and C1q levels in synapses. On ...

The composition of nodes that effectively transmit sinusoidal waves in a model network resembling C. elegans' electrical synapses network changes according to the waves' wavenumber.

LTS activity was closely correlated with inhibitory postsynaptic potentials in neighboring FS interneurons and excitatory neurons. Synchronized LTS activity required electrical synapses ...

Layer 5 pyramidal neurons, crucial for brain information processing, vary significantly in their synaptic protein composition based on neuron type.

By reexamining 3D images used to map the connections between brain cells, researchers are uncovering new information about a ...