Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. Figure 2: Destructive pathways: SUMOylation of Mdm2 ...

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

The tumor suppressor p53 is regarded as guardian of the genome by preventing malignant transformation and tumorigenesis. In response to various stress signals, such as DNA damage, nucleolar stress, ...

Analyst Joseph Pantginis from H.C. Wainwright reiterated a Buy rating on Aprea Therapeutics (APRE – Research Report) and keeping the price ...

▎药明康德内容团队编辑（来源：北京大学）DNA损伤修复在维持基因组稳定性中发挥关键作用，其相关基因的突变可能危害基因组完整性，并增加癌症发生的风险。顺铂（Cisplatin）和电离辐射（IR）等DNA损伤药物被广泛用于肿瘤治疗，但临床治疗中不断发现病 ...

Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient p53-independent ... Representative cell cycle analysis of total DNA content ...

Department of Gastrointestinal Surgery, Zhejiang International Scientific and Technological Cooperation Base of Translational Cancer Research, The Second Affiliated Hospital and Yuying Children’s ...

Jan. 15, 2025 — A groundbreaking study finds evidence that land was inherited through the female line in Iron Age Britain, with husbands moving to live with their wife's community. This is ...

2024年12月11日，北京大学魏文胜团队在Cell Reports杂志在线发表题为“Mapping functional elements of the DNA damage response through base editor screens”的研究 ... 此外，研究还鉴定出多个与DNA损伤修复相关的重要翻译后修饰位点，例如p53的K120是调控其凋亡功能的重要乙酰化位点 ...

Several human genetic syndromes have long been recognized to be defective in DNA repair mechanisms. This was first discovered by Cleaver (1968), who showed that cells from patients with xeroderma ...