Moreover, glucocorticoids produce distinct therapeutically relevant effects. Genomic effects are mediated by cytosolic receptors that alter expression of specific genes. Specific non-genomic effects ...

which results in the formation of receptor homo- or hetero-dimers. Dimerization of cytosolic TIR domains is required for the recruitment of adaptor molecules. All TLRs, except TLR-3, signal ...

The receptor for advanced glycation end products ... a transmembrane domain (TM), and a cytosolic terminal (CT). Soluble ecRAGE is generated by the activity of ADAM10, which presumably cleaves ...

manchester.ac.uk Objectives Autoantibodies directed against cytosolic 5′-nucleotidase 1A have been identified in many patients with inclusion body myositis. This retrospective study investigated the ...

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An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

In resting immune cells, a functionally coupled network of membrane transporters, ion channels, and calcium binding proteins maintains the cytosolic calcium concentration in the nanomolar range. The ...

Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China ...

Tumor chemotherapy resistance arises frequently and limits high-grade serous ovarian cancer (HGSOC) patient survival. Focal adhesion kinase (FAK) is an intracellular protein–tyrosine kinase encoded by ...