which results in the formation of receptor homo- or hetero-dimers. Dimerization of cytosolic TIR domains is required for the recruitment of adaptor molecules. All TLRs, except TLR-3, signal ...

manchester.ac.uk Objectives Autoantibodies directed against cytosolic 5′-nucleotidase 1A have been identified in many patients with inclusion body myositis. This retrospective study investigated the ...

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An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.