This three-step pathway involves the enzymes carboxylesterase, cytidine deaminase and thymidine phosphorylase (Figure 1), all of which are expressed in hepatic and tumor tissue. In particular the ...

including one called '23C9' that we later designated 'activation-induced cytidine deaminase' (AID). Additional cDNA molecules encoding proteins known to be induced by cytokine stimulation ...

Azacitidine and decitabine are HMAs. Following oral administration, HMAs are rapidly degraded by cytidine deaminase, resulting in poor oral bioavailability. Cedazuridine is a cytidine deaminase ...