Concomitant CYP2C9 inhibitors: max Arthrotec 50 twice daily. See full labeling. Osteoarthritis: Arthrotec 50 three times daily. For patients who experience intolerance, Arthrotec 75 twice daily or ...
Severe renal impairment (CrCl<30mL/min), ESRD, mild to moderate hepatic impairment: reduce max dose by 25%; if concomitant strong CYP3A4/CYP2C9 inhibitors: may need dose reduction. Consider ...
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