This interaction initiates a series of proximal events including tyrosine phosphorylation of the CD3 and TCRζ chains, recruitment, and activation of the protein tyrosine kinases Lck and ZAP70, ...

T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for ...

A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor ...

An alternative to antigen-specific expansion is the transduction of patient T cells, usually via lentivirus, with a chimeric antigen receptor (CAR) specific for a tumor antigen. Such receptors are ...

The following antibodies were used: from Cell Signaling Technology, phospho-FGFR Tyr653/654 (Cell Signaling Technology ... #BE0001-2) and 1 μg/ml human anti-CD28 antibody (InVivoMAb, #BE0248) for 24 ...

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The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical ...

A study explores the molecular dynamics of CD28.ζ-CAR and 4-1BB.ζ-CAR T cells at the immune synapse, where CAR T cells bind ...

The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...

A groundbreaking study from Baylor College of Medicine explores how two types of CAR T cells target cancer, shedding light on ...

A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor ...