Biosynthetic pathways for secondary metabolites usually make many products, not just one. In this Commentary, we consider why molecular promiscuity might be an evolutionarily advantageous feature ...

Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen 9747 AG, The Netherlands ...

They show the parasites that cause leishmaniasis are vulnerable via a different pathway for biosynthesis of their ergosterol, known as the CYP5122A1 enzyme. Therefore, azole antifungals targeting ...

FIGURE 2. P450-active cycle exemplified for GPA crosslinking together with the heme oxygenase degradation pathway. PCP-X construct. The PCP-X construct from the kistamicin NRPS was expressed and ...

3.5 Comparative expression analysis of GSL biosynthesis pathway between ZS11 and ZY821 Based on the above transcriptome dataset constructed in this study, we compared the expression profiles of GSL ...

Biosynthesis of essential hormones is often complex and redundant. Two independent genetic screens have converged to support a previously conjectured auxin biosynthetic pathway that is responsible ...

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Singapore-MIT Alliance for Research and Technology, Antimicrobial Resistance ...

In everyday life, when things turn out the opposite of what you expect, it's usually a cause for frustration. In science, ...

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...

Creation of all things; creation of Adam and Eve; temptation by Satan; Adam and Eve rebel against God and forfeit Garden of Eden. On that day, Adam and Eve, the father and mother of all mankind, chose ...

Pyruvate occupies a central node in carbohydrate metabolism such that how it is produced and consumed can optimize a cell for energy production or biosynthetic capacity. This has been primarily ...