利用合成致死（Synthetic Lethality）特异性杀伤肿瘤细胞，是近年来肿瘤临床治疗的一项重要尝试。特别是靶向 BRCA1/BRCA2 突变的 PARP 抑制剂（PARPi），自问世以来便展现出显著的临床疗效，为基于合成致死原理的靶向药物开发提供了积极的实践验证。 然而，PARPi 的 ...

Kimberlin, who previously collaborated with Dr. Jonas Salk to develop the first FDA-approved cell-based immunotherapy, ...

Researchers explored the influence the mechanical stiffening of the tumor cell's environment may have on the structure and function of the nucleus. In 2022 alone, over 20 million people were ...

Are you looking to take your health to another level in 2025? Learn everything you need to know about Apple Fitness+ new ...

Jan. 14, 2025 — Using advanced imaging techniques and precise microfluidics control to stretch out curly DNA into a straight line, new research demonstrates techniques for stretching and ...

Retraction of 'COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells'.

In conclusion, we would like to emphasize two points: first, the importance of the cis conformation of peptide bonds in protein structures, especially if it is a Xaa–nonPro peptide bond, and ...

The most common mutations associated with ovarian cancer include those in the breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2) and those tied to Lynch syndrome, a disease that also ...

Taken together, epigenetic changes that alter chromatin structure have surpassed the proof of principle stage and now offer new dimensions for cancer diagnosis and therapy. With expanding use of ...

Fred Hutch grew from a regional cancer center into a world-class biomedical research and clinical care institution known for ...

A model showing how metallic bonds are formed - the first diagram shows the outer electrons in their atoms, and the second diagram shows that the electrons have become delocalised ...