Uniquely, only in the nucleus does unfolded protein activate a robust p53-driven transcriptional response and a transient p53-independent ... The compartmentalization of eukaryotic cells, facilitated ...

He, H.J., Cen, X.H., Liang, Y.J., Zhong, J.M., Deng, J.H. and Jiang, Y.J. (2025) Progress in the Regulation of Lipid Metabolism by the Orphan Nuclear Receptor Nur77. Journal of Biosciences and ...

When it comes to financial regulation in America, “no rational person would have set out to design the current system of regulation. It is inefficient and inequitable, sometimes completely ...

Thus, we next used siRNA to knock down the p53 protein in MGC-803 cells. An Annexin V-APC/7-AAD apoptosis assay revealed that NOLC1 single-knockdown cells were more sensitive to Cis than were NC cells ...

suggesting that p53 evaluation may predict the response of CD22-positive leukemic cells to a Calicheamicin derivative. These findings strengthen our hypothesis that Chk1 phosphorylation triggers a ...

Whereas the high glycolytic rate (the so-called Warburg metabolism) and the suppression of apoptosis are key elements for the establishment and maintenance of cancer cells, mitochondrial dysfunction ...