The first round of a debate is most useful for isolating the crux. I therefore kindly ask for one more public round. This would be most beneficial, not just for me, but also for the many Alzforum ...

Gut-Brain Connection. People who have CD83+ microglia in their brains also have HCMV (top left) and IgG4 (top right) in their ...

Notably, this coupling crumbles with age in mice. Restoring it not only bolstered neuronal energy reserves, but also strengthened synaptic signaling and counteracted memory loss in old animals.

The easiest way to track down "when" in a chronic disorder like AD is with the causal quartet, those carrying disease-causing mutations in APP, PSEN1, PSEN2 and SORL1, and, as you expand, including ...

While all three genotypes of mice performed similarly to wild-type animals on multiple behavioral and spatial memory tests, ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

Unknown. Multiple in silico algorithms yielded conflicting results.

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SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

Unknown; predicted pathogenic in silico (CADD>20).

"The neurologist diagnosed conversion disorder (see Medline). I should not have believed that. We went to counseling sessions for a year but nothing happened." —Caregiver. Families with eFAD tell ...