Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single molecules may have ...

The ultimate effect of a signal from one neuron on the next neuron depends on the function of the synapse, which is based on the type of neurotransmitter released. Excitatory synapses send signals ...

We have complemented this approach by testing the response to miniature excitatory postsynaptic currents (EPSCs) whose rate of release was elevated at many synapses independently through the local ...

Aberrant synapse development can have pathological consequences for circuit function as demonstrated by the manifestation of devastating neurological impairments, including epilepsy and autism ...

The junctions between two brain cells (neurons) are called synapses, which are essential for neuronal signal transmission and ...

Complementary, inhibitory synapses account for the long-lasting stability of excitatory synaptic modifications, providing the ...

An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...