Aminoacyl-tRNA synthetase aminoacylates the cognate transfer RNA (tRNA) with the cognate amino acid, which will be incorporated into the nascent polypeptide chain on the ribosome. In addition to ...

Defects in tRNA biology, such as mutations in tRNA genes or aminoacyl-tRNA synthetases, can lead to various diseases, including: Understanding the mechanisms of tRNA-related diseases and the potential ...

Within the ribosome, the mRNA and aminoacyl-tRNA complexes are held together closely, which facilitates base-pairing. The rRNA catalyzes the attachment of each new amino acid to the growing chain.

In order to facilitate these applications, we have: 1) Developed new aminoacyl-tRNA synthetase/tRNA platforms that enable site-specific incorporation of previously inaccessible structural classes of ...