Transmembrane proteins involve various physiological functions, including protein ligation, recognition, transport, anchoring, and transduction. Several diseases are connected with abnormalities ...

Transporters carry a molecule (such as glucose) from one side of the plasma membrane to the other. Receptors can bind an extracellular molecule (triangle), and this activates an intracellular ...

VLPs can display membrane proteins in their full natural conformation on the surface of virus-like particles, resulting in full-length transmembrane proteins suitable for immunization and antibody ...

New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane ...

combined groups: −5.4 mV (p < 0.001) CF = cystic fibrosis; FEV 1 = forced expiratory volume in 1 second. The classes of cystic fibrosis transmembrane conductance regulator (CFTR) mutations.

"This opens up new opportunities for drugging adhesion GPCRs, because now we are showing that the extracellular region is communicating with the transmembrane region," said Demet Araç, Ph.D ...