Models of depression pathogenesis have advanced over the years. The ‘monoamine hypothesis’ primarily attributes the cause of depression to an imbalance or deficiency of monoamine ...

Despite the replacement of the monoamine hypothesis of depression with a more comprehensive understanding of multiple influencing factors in the pathology of depression, it is clear that elevating ...

For many years, the prevailing hypothesis of depression has been that a deficit in monoamine neurotransmitters, notably norepinephrine and serotonin, underlies depression. The monoamines are named ...