They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...
In the mid-1980s, it was finally identified as the microtubule-associated protein tau. Tau has been implicated in the assembly and stabilization of microtubules, although its exact role is still ...
The increasing knowledge on how protein tau is organized in live cells has shown that the protein forms nanometer-sized hotspots which are different from tau microtubules. These hotspots, essential ...