▎药明康德内容团队编辑（来源：同济大学）成体干细胞来源的类器官是一种重要的体外研究工具，能够高度模拟体内组织的发育、稳态维持和再生过程。凭借其接近体内真实环境的细胞组成、组织结构及功能特征，类器官已成为研究发育机制、疾病发生发展以及药物筛选的重要平台 ...

We will use a simplified version of the small intestine in the lab in the form of an organoid. An organoid is a three-dimensional, miniaturized model of an organ that mimics its activity and ...

we exposed mouse and human intestinal organoids (self-organized 3D tissues derived from intestine-resident stem cells) to RANKL. We observed a reorganization and marked expansion of the intestinal ...

Technology Networks spoke with Dr. Thomas Dennison, University of Cambridge, to learn more about the advantages of using ...

Researchers from the Organoid group at the Hubrecht Institute have developed a new way to grow organoids. Organoids are tiny ...

3D replicas of the human and mouse small intestine. They grew these "organoids" with the help of specialized chemicals. They then exposed the cells within the mini-intestines to RANK, which ...

During homeostasis, the ISC niche exists in the crypt together with differentiated cells (e.g., lysozyme producing Paneth cells in the small intestine) and stromal cells at the underlying mesenchyme.