Disrupting the fast-paced but fragile pyrimidine synthesis pathways, as some chemotherapies are designed to do, can rapidly starve cancer cells and spontaneously lead to them dying (apoptosis).

Pyrimidine analogs, such as 5-fluorouracil (5-FU) and gemcitabine, are used as chemotherapeutic agents to treat various types of cancer. These drugs interfere with DNA synthesis and replication, ...

In the summer of 2016, he undertook a placement at the Institute of Cancer Research with Professor Keith Jones, working on expanding the scope of a pyrazolo[3,4-d]pyrimidine synthesis. Jess Cross ...

The purine structure consists of a pyrimidine ring (positions 1 to 6 ... as GTP (guanosine triphosphate), which is involved in cellular signaling and protein synthesis. In addition to their role in ...