Pyrimidine analogs, such as 5-fluorouracil (5-FU) and gemcitabine, are used as chemotherapeutic agents to treat various types of cancer. These drugs interfere with DNA synthesis and replication, ...

Disrupting the fast-paced but fragile pyrimidine synthesis pathways, as some chemotherapies are designed to do, can rapidly starve cancer cells and spontaneously lead to them dying (apoptosis).

In the summer of 2016, he undertook a placement at the Institute of Cancer Research with Professor Keith Jones, working on expanding the scope of a pyrazolo[3,4-d]pyrimidine synthesis. Jess Cross ...

The purine structure consists of a pyrimidine ring (positions 1 to 6 ... also a component of important biomolecules such as GTP (guanosine triphosphate), which is involved in cellular signaling and ...