an animal disease linked to misfolded prion protein (PrP). In 2001, Soto's group described the development of the 'protein misfolding cyclical amplification' (PMCA) assay, in which brain tissue ...
Figure 1: QUIC reactions seeded with brain homogenates and CSF samples from normal or scrapie-affected hamsters. These observations suggest that a diagnostic test for prion infections based on CSF ...
"Scrapie" is the old Scottish shepherds' name for a disease of their sheep which has been known for several centuries. It is the original example of a group of diseases, known as the ...
Please note that audiobooks and ebooks purchased from this site must be accessed on the Princeton University Press app. After you make your purchase, you will receive ...
The clinical worsening after microglia envelop neurons suggests the phenomenon is harmful, the authors noted. “With disease progression, microglial behavior changes from positive to negative,” ...
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Log out ...
These prions cluster together, forming lengthy fibers that eventually turn into plaques, akin to the process by which amyloid-beta and tau proteins accumulate and expand in the brain in cases of ...