A naturally occurring p53 isoform, called Δ40p53 (or ΔNp53), causes accelerated aging in mice when expressed together with WTp53. We generated genome-edited human cell lines that express Δ40p53:WTp53 ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.