The discovery of the Bcl-2 protein family, as well as p53 and its involvement in regulating apoptosis, and the CD95 (also known as FAS or APO1) pathway, led to an understanding of the molecular ...

Selective modulation of the apoptotic machinery has been the goal of oncology developers for more than two decades. The field continues to face special challenges. Many of the targets are ...

The p53 signaling pathway determines whether ... the researchers connected the perceptein circuit's output to a caspase-3 apoptosis pathway. This linkage allowed the circuit to trigger cell ...