p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

Dissection of the signalling pathways mediating apoptosis — controlled cell death ... TNF, NF-κB and p53. This interest in part stems from the substantial potential to therapeutically ...

The biological effects of p53 pathway variants at the molecular level in primary cells or in vivo still need to be determined. The design of genetically engineered mice using knock-in and knockout ...

Westlake University in China and the California Institute of Technology have designed a protein-based system inside living ...